L-ThreoninaMide, D-alanyl-L-seryl-L-threonyl-L-threonyl-L-threonyl-L-asparaginyl-L-tyrosyl-
(D-ALA1)-PEPTIDE T AMIDE
CAS: 106362-34-9
Molecular Formula: C35H56N10O15
L-ThreoninaMide, D-alanyl-L-seryl-L-threonyl-L-threonyl-L-threonyl-L-asparaginyl-L-tyrosyl- - Names and Identifiers
L-ThreoninaMide, D-alanyl-L-seryl-L-threonyl-L-threonyl-L-threonyl-L-asparaginyl-L-tyrosyl- - Physico-chemical Properties
| Molecular Formula | C35H56N10O15 |
| Molar Mass | 856.88 |
| Density | 1.415±0.06 g/cm3(Predicted) |
| Boling Point | 1514.3±65.0 °C(Predicted) |
| pKa | 9.82±0.15(Predicted) |
| Storage Condition | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| In vitro study | DAPTA is a non-toxic inhibitor of experimental antiviral invasion. DAPTA effectively inhibited the binding of cd4-dependent gp120 Bal and CM235 to CCR5 with an IC50 of 0.06 nM and 0.32 nM, respectively. In immunoprecipitation experiments, 1 nM DAPTA was able to prevent the formation of the complex of gp120/sCD4 with CCR5. By confocal microscopy, FITC-DAPTA and CCR5 were observed. DAPTA increased the release of Th2 cytokines by IL-4, IL-10 and IL-13, inducing an effective Virus suppression state in infected macrophages; both pro-inflammatory factor IL-1 and TNFα production were inhibited. Thus, DAPTA enhances the expression of Th2 cytokines, inhibiting Virus replication of macrophages. |
| In vivo study | DAPTA treatment resulted in a decrease in plasma levels of inflammatory factors IL-1, IL-6 and TNFα. Peptide T(DAPTA) prevents gp120-related neuronal cell death, thereby preventing gp120-related neurological deficits. |
L-ThreoninaMide, D-alanyl-L-seryl-L-threonyl-L-threonyl-L-threonyl-L-asparaginyl-L-tyrosyl- - Risk and Safety
| WGK Germany | 3 |
L-ThreoninaMide, D-alanyl-L-seryl-L-threonyl-L-threonyl-L-threonyl-L-asparaginyl-L-tyrosyl- - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.167 ml | 5.835 ml | 11.67 ml |
| 5 mM | 0.233 ml | 1.167 ml | 2.334 ml |
| 10 mM | 0.117 ml | 0.584 ml | 1.167 ml |
| 5 mM | 0.023 ml | 0.117 ml | 0.233 ml |
Last Update：2024-01-02 23:10:35
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Spot supply
Product Name: (D-ALA1)-PEPTIDE T AMIDE Visit Supplier Webpage Request for quotationCAS: 106362-34-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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